Enter your SMTP mail server settings. If you are unsure what your settings are, you may have to ask the person at your company who setup your email account, or the company that hosts your email. Here are a few tips to help you out:
If you have a @yourcompanyname.com email address, the SMTP server is typically smtp.yourcompanyname.com.
The Email User Name is typically your full email address.
The Email Password is typically the password used to access your email.
If you use gmail, the SMTP server is typically "smtp.gmail.com"
If you use Yahoo!, the SMTP server is typically "smtp.mail.yahoo.com".
If you use Yahoo! Plus, the SMTP server is typically "plus.smtp.mail.yahoo.com".
If you use Hotmail, the SMTP server is typically "smtp.live.com".
If you use MSN, the SMTP server is typically "smtp.email.msn.com".
For the Port, you can typically leave this blank. If you do, Method will use port 25 for non-SSL accounts, port 587 for gmail accounts, and port 465 for all other SSL accounts.
Click Save & Send Test Email.
Optional: if you would like to specify separate email server settings per user, go to Customize > Users, edit each user, and in Step 2 un-check Use default email server settings? and specify the server settings for that user.
Troubleshooting tips for email over SSL:
Exchange 2010 by default will support only NTLM authentication for SMTP. To correct this modify the receive connector to also allow AUTH LOGIN over TLS connections and that should work.